1ae7
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1AE7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1AE7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Structure known Active Sites: CAL and CNR. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AE7 OCA]]. |
==Reference== | ==Reference== | ||
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1568473 1568473] | The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1568473 1568473] | ||
| + | [[Category: Notechis scutatus scutatus]] | ||
| + | [[Category: Phospholipase A(2)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Eaker, D.]] | [[Category: Eaker, D.]] | ||
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[[Category: venom]] | [[Category: venom]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:38:24 2007'' |
Revision as of 08:33, 30 October 2007
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NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2
Overview
The three-dimensional structure of notexin has been solved by molecular, replacement methods. The structure has been refined at 2.0 A resolution to, a crystallographic R-value of 16.5% with good stereo-chemistry. The core, of the protein is very similar to other phospholipase A2s (PLA2 s) but, several parts of the molecule are distinctly different. The most, significant differences from PLA2 s from bovine pancreas and rattlesnake, occur in the stretches 56-80 and 85-89. Residue 69, which has been shown, to be important for phospholipase binding, has a different conformation, and different interactions than in other known PLA2s. The C alpha, positions for residues 86-88 differ by about 6 A from both the bovine and, the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a, ... [(full description)]
About this Structure
1AE7 is a [Single protein] structure of sequence from [Notechis scutatus scutatus] with SO4 as [ligand]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Sites: CAL and CNR. Full crystallographic information is available from [OCA].
Reference
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:1568473
Page seeded by OCA on Tue Oct 30 10:38:24 2007
