1p7b
From Proteopedia
(New page: 200px<br /><applet load="1p7b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p7b, resolution 3.65Å" /> '''Crystal structure of...) |
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| - | [[Image:1p7b.gif|left|200px]]<br /><applet load="1p7b" size=" | + | [[Image:1p7b.gif|left|200px]]<br /><applet load="1p7b" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1p7b, resolution 3.65Å" /> | caption="1p7b, resolution 3.65Å" /> | ||
'''Crystal structure of an inward rectifier potassium channel'''<br /> | '''Crystal structure of an inward rectifier potassium channel'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The KirBac1.1 channel belongs to the inward-rectifier family of potassium | + | The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway. |
==About this Structure== | ==About this Structure== | ||
| - | 1P7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with K as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1P7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Burkholderia pseudomallei]] | [[Category: Burkholderia pseudomallei]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Antcliff, J | + | [[Category: Antcliff, J F.]] |
| - | [[Category: Ashcroft, F | + | [[Category: Ashcroft, F M.]] |
[[Category: Cuthbertson, J.]] | [[Category: Cuthbertson, J.]] | ||
| - | [[Category: Doyle, D | + | [[Category: Doyle, D A.]] |
[[Category: Ezaki, T.]] | [[Category: Ezaki, T.]] | ||
| - | [[Category: Gulbis, J | + | [[Category: Gulbis, J M.]] |
[[Category: Kuo, A.]] | [[Category: Kuo, A.]] | ||
| - | [[Category: Lowe, E | + | [[Category: Lowe, E D.]] |
[[Category: Rahman, T.]] | [[Category: Rahman, T.]] | ||
[[Category: Zimmer, J.]] | [[Category: Zimmer, J.]] | ||
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[[Category: transmembrane helices]] | [[Category: transmembrane helices]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:53 2008'' |
Revision as of 12:25, 21 February 2008
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Crystal structure of an inward rectifier potassium channel
Overview
The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
About this Structure
1P7B is a Single protein structure of sequence from Burkholderia pseudomallei with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the potassium channel KirBac1.1 in the closed state., Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA, Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:12738871
Page seeded by OCA on Thu Feb 21 14:25:53 2008
