1he9
From Proteopedia
(New page: 200px<br /><applet load="1he9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1he9, resolution 2.40Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size=" | + | [[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1he9, resolution 2.40Å" /> | caption="1he9, resolution 2.40Å" /> | ||
'''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''<br /> | '''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great | + | Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting. |
==About this Structure== | ==About this Structure== | ||
| - | 1HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http:// | + | 1HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Barbieri, J | + | [[Category: Barbieri, J T.]] |
[[Category: Renault, L.]] | [[Category: Renault, L.]] | ||
[[Category: Wittinghofer, A.]] | [[Category: Wittinghofer, A.]] | ||
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[[Category: virulence factor]] | [[Category: virulence factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:21 2008'' |
Revision as of 11:00, 21 February 2008
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CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN
Overview
Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.
About this Structure
1HE9 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Structure of the ExoS GTPase activating domain., Wurtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E, FEBS Lett. 2001 Feb 23;491(1-2):26-9. PMID:11226412
Page seeded by OCA on Thu Feb 21 13:00:21 2008
