3gnv

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{{STRUCTURE_3gnv| PDB=3gnv | SCENE= }}
{{STRUCTURE_3gnv| PDB=3gnv | SCENE= }}
===HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b===
===HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b===
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{{ABSTRACT_PUBMED_19507864}}
{{ABSTRACT_PUBMED_19507864}}
==About this Structure==
==About this Structure==
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3GNV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNV OCA].
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[[3gnv]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_isolate Hepatitis c virus isolate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNV OCA].
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==See Also==
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*[[RNA polymerase|RNA polymerase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19507864</ref><references group="xtra"/>
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<ref group="xtra">PMID:019507864</ref><references group="xtra"/>
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[[Category: Hepatitis c virus isolate]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: Viruses]]
 
[[Category: Bondt, H De.]]
[[Category: Bondt, H De.]]
[[Category: Nyanguile, O.]]
[[Category: Nyanguile, O.]]
[[Category: 1 5-benzodiazepine]]
[[Category: 1 5-benzodiazepine]]
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[[Category: Acetylation]]
 
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]
[[Category: Cell membrane]]
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[[Category: Transferase]]
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[[Category: Ubl conjugation]]
 
[[Category: Viral nucleoprotein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:20:17 2009''
 

Revision as of 02:08, 26 July 2012

Image:3gnv.png

Template:STRUCTURE 3gnv

Contents

HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b

Template:ABSTRACT PUBMED 19507864

About this Structure

3gnv is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus isolate. Full crystallographic information is available from OCA.

See Also

Reference

  • Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. J Med Chem. 2009 Jul 23;52(14):4099-102. PMID:19507864 doi:10.1021/jm9005548

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OCA

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