1l6z

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(New page: 200px<br /><applet load="1l6z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l6z, resolution 3.32&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1l6z.jpg|left|200px]]<br /><applet load="1l6z" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1l6z, resolution 3.32&Aring;" />
caption="1l6z, resolution 3.32&Aring;" />
'''CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY'''<br />
'''CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY'''<br />
==Overview==
==Overview==
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CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms, of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a, murine coronavirus. Here we report the crystal structure of soluble murine, sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV, neutralizing activity. Its N-terminal domain has a uniquely folded CC', loop that encompasses key virus-binding residues. This is the first atomic, structure of any member of the CEA family, and provides a prototypic, architecture for functional exploration of CEA family members. We discuss, the structural basis of virus receptor activities of murine CEACAM1, proteins, binding of Neisseria to human CEACAM1, and other homophilic and, heterophilic interactions of CEA family members.
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CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC' loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.
==About this Structure==
==About this Structure==
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1L6Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NDG and NAG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1L6Z OCA].
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1L6Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6Z OCA].
==Reference==
==Reference==
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Bergelson, J.M.]]
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[[Category: Bergelson, J M.]]
[[Category: Duke, N.]]
[[Category: Duke, N.]]
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[[Category: Holmes, K.V.]]
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[[Category: Holmes, K V.]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak, A.]]
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[[Category: Liu, J.H.]]
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[[Category: Liu, J H.]]
[[Category: Meijers, R.]]
[[Category: Meijers, R.]]
[[Category: Tan, K.]]
[[Category: Tan, K.]]
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[[Category: Wang, J.H.]]
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[[Category: Wang, J H.]]
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[[Category: Zelus, B.D.]]
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[[Category: Zelus, B D.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
[[Category: NAG]]
[[Category: NAG]]
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[[Category: ig-like domain]]
[[Category: ig-like domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:34:29 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:41:59 2008''

Revision as of 11:42, 21 February 2008

Image:1l6z.jpg

1l6z, resolution 3.32Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY

Overview

CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC' loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.

About this Structure

1L6Z is a Single protein structure of sequence from Mus musculus with and as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family., Tan K, Zelus BD, Meijers R, Liu JH, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV, Wang JH, EMBO J. 2002 May 1;21(9):2076-86. PMID:11980704

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