3jz2

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===Crystal structure of human thrombin mutant N143P in E* form===
===Crystal structure of human thrombin mutant N143P in E* form===
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{{ABSTRACT_PUBMED_19846563}}
==Disease==
==Disease==
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==Reference==
==Reference==
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<ref group="xtra">PMID:19846563</ref><ref group="xtra">PMID:18250335</ref><ref group="xtra">PMID:15152000</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:42:36 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 12:55:58 2010''

Revision as of 10:55, 13 January 2010

Image:3jz2.png

Template:STRUCTURE 3jz2

Contents

Crystal structure of human thrombin mutant N143P in E* form

Template:ABSTRACT PUBMED 19846563

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3JZ2 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Niu W, Chen Z, Bush-Pelc LA, Bah A, Gandhi PS, Di Cera E. Mutant N143P reveals how Na+ activates thrombin. J Biol Chem. 2009 Dec 25;284(52):36175-85. Epub 2009 Oct 21. PMID:19846563 doi:10.1074/jbc.M109.069500
  • Gandhi PS, Chen Z, Mathews FS, Di Cera E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1832-7. Epub 2008 Feb 4. PMID:18250335
  • Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200

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