1tqx
From Proteopedia
(New page: 200px<br /><applet load="1tqx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tqx, resolution 2.00Å" /> '''Crystal Structure of...) |
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| - | [[Image:1tqx.gif|left|200px]]<br /><applet load="1tqx" size=" | + | [[Image:1tqx.gif|left|200px]]<br /><applet load="1tqx" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1tqx, resolution 2.00Å" /> | caption="1tqx, resolution 2.00Å" /> | ||
'''Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum'''<br /> | '''Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate | + | The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 A resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM-barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action of this enzyme. This structure is solved in the framework of the Structural Genomics of Pathogenic Protozoa (SGPP) consortium. |
==About this Structure== | ==About this Structure== | ||
| - | 1TQX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7] with SO4 and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1TQX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bosch, J.]] | [[Category: Bosch, J.]] | ||
[[Category: Caruthers, J.]] | [[Category: Caruthers, J.]] | ||
| - | [[Category: Hol, W | + | [[Category: Hol, W G.J.]] |
| - | [[Category: SGPP, Structural | + | [[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: tim barrel]] | [[Category: tim barrel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:16:25 2008'' |
Revision as of 13:16, 21 February 2008
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Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum
Overview
The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 A resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM-barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action of this enzyme. This structure is solved in the framework of the Structural Genomics of Pathogenic Protozoa (SGPP) consortium.
About this Structure
1TQX is a Single protein structure of sequence from Plasmodium falciparum 3d7 with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum., Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG, Proteins. 2006 Feb 1;62(2):338-42. PMID:16304640
Page seeded by OCA on Thu Feb 21 15:16:25 2008
Categories: Plasmodium falciparum 3d7 | Single protein | Bosch, J. | Caruthers, J. | Hol, W G.J. | SGPP, Structural Genomics of Pathogenic Protozoa Consortium. | SO4 | ZN | Protein structure initiative | Psi | Ribulose phosphate epimerase | Sgpp | Structural genomics | Structural genomics of pathogenic protozoa consortium | Tim barrel
