1pm3
From Proteopedia
(New page: 200px<br /><applet load="1pm3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pm3, resolution 3.15Å" /> '''MTH1859'''<br /> ==...) |
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| - | [[Image:1pm3.gif|left|200px]]<br /><applet load="1pm3" size=" | + | [[Image:1pm3.gif|left|200px]]<br /><applet load="1pm3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1pm3, resolution 3.15Å" /> | caption="1pm3, resolution 3.15Å" /> | ||
'''MTH1859'''<br /> | '''MTH1859'''<br /> | ||
==Overview== | ==Overview== | ||
| - | MTH1859 from Methanobacterium thermoautotrophicum is a 77 residue protein | + | MTH1859 from Methanobacterium thermoautotrophicum is a 77 residue protein representing a conserved family of functionally uncharacterized proteins. We solved the crystal structure of MTH1859 by single wavelength anomalous diffraction phasing using selenomethionine labeled protein. MTH1859 adopts a mainly anti-parallel all-beta-fold. The beta-sheet is heavily bent to form a U-structure that is closed through a loop. The monomer structure possesses similarities to the photoreaction center (PRC) domain fold, but the protein employs a unique oligomerization scheme. Two monomers of MTH1859 occupy the asymmetric unit and dimerize in a head-to-head fashion. Crystal packing interactions identify a second protein-protein interaction interface at the MTH1859 tails which can simultaneously bind two partner molecules. These interactions lead to the formation of a honeycomb structure and suggest that the family of MTH1859-like proteins might function as adapters for protein complex assembly. |
==About this Structure== | ==About this Structure== | ||
| - | 1PM3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http:// | + | 1PM3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Methanothermobacter thermautotrophicus]] | [[Category: Methanothermobacter thermautotrophicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: NESG, Northeast | + | [[Category: NESG, Northeast Structural Genomics Consortium.]] |
[[Category: Steegborn, C.]] | [[Category: Steegborn, C.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
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[[Category: unknown function]] | [[Category: unknown function]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:09 2008'' |
Revision as of 12:30, 21 February 2008
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MTH1859
Overview
MTH1859 from Methanobacterium thermoautotrophicum is a 77 residue protein representing a conserved family of functionally uncharacterized proteins. We solved the crystal structure of MTH1859 by single wavelength anomalous diffraction phasing using selenomethionine labeled protein. MTH1859 adopts a mainly anti-parallel all-beta-fold. The beta-sheet is heavily bent to form a U-structure that is closed through a loop. The monomer structure possesses similarities to the photoreaction center (PRC) domain fold, but the protein employs a unique oligomerization scheme. Two monomers of MTH1859 occupy the asymmetric unit and dimerize in a head-to-head fashion. Crystal packing interactions identify a second protein-protein interaction interface at the MTH1859 tails which can simultaneously bind two partner molecules. These interactions lead to the formation of a honeycomb structure and suggest that the family of MTH1859-like proteins might function as adapters for protein complex assembly.
About this Structure
1PM3 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the putative adapter protein MTH1859., Ye H, Chen TC, Xu X, Pennycooke M, Wu H, Steegborn C, J Struct Biol. 2004 Nov;148(2):251-6. PMID:15477104
Page seeded by OCA on Thu Feb 21 14:30:09 2008
