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Chad Sorenson sandbox 1

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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }}
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{{STRUCTURE_1gux| PDB=1gux | SCENE= }}
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===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===
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===RB POCKET BOUND TO E7 LXCXE MOTIF===
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Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
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{{ABSTRACT_PUBMED_9495340}}
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The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A (<scene name='Chad_Sorenson_sandbox_1/Domain_a/1'>(Domain A)</scene>)and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.
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==About this Structure==
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1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA].
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Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914
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==Reference==
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<ref group="xtra">PMID:9495340</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Human papillomavirus]]
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[[Category: Lee, J O.]]
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[[Category: Pavletich, N P.]]
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[[Category: Russo, A A.]]
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[[Category: Retinoblastoma]]
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[[Category: Tumor suppressor protein]]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''

Revision as of 01:31, 29 October 2009


PDB ID 1gux

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1gux, resolution 1.85Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



RB POCKET BOUND TO E7 LXCXE MOTIF

Template:ABSTRACT PUBMED 9495340

About this Structure

1GUX is a 3 chains structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.

Reference

  • Lee JO, Russo AA, Pavletich NP. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340 doi:10.1038/36038

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