B-cell lymphoma protein

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	{{STRUCTURE_1g5m | PDB=1g5m | SCENE= }}		{{STRUCTURE_1g5m | PDB=1g5m | SCENE= }}
	[[Image:Bcl-2_3D.jpg|left|200px]]		[[Image:Bcl-2_3D.jpg|left|200px]]
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	==Overview==		==Overview==

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Revision as of 00:58, 29 October 2009

spinqualitylabelsall models PDB ID 1g5m Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1g5m, 1 NMR models ()
Related:	1bxl, 1g5j, 1g5o
Structural annotation: Resources: CATH : 1G5Ma00 InterPro : Ipr004725, Ipr013278, Ipr003093, Ipr000712, Ipr002475, Ipr012238 Pfam : PF00452 SCOP : d1g5ma_ UniProt : P10415
Functional annotation: Cellular component: mitochondrial outer membrane membrane cytoplasm nucleus endoplasmic reticulum nuclear membrane mitochondrion cytosol integral to membrane Biological process: response to nicotine regulation of mitochondrial membrane potential pigmentation anti-apoptosis negative regulation of mitochondrial depolarization response to radiation regulation of mitochondrial membrane permeability regulation of protein homodimerization activity response to iron ion response to toxin female pregnancy regulation of protein heterodimerization activity hair follicle morphogenesis apoptosis positive regulation of cell proliferation regulation of apoptosis humoral immune response defense response to virus negative regulation of neuron apoptosis negative regulation of cellular pH reduction release of cytochrome c from mitochondria negative regulation of apoptosis neuron apoptosis regulation of viral genome replication Molecular function: protein heterodimerization activity identical protein binding protein binding protease binding protein homodimerization activity BH3 domain binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Overview

Bcl-2 is a family of genes and proteins that govern the mitochondrial membrane permeabilization (MMP). Bcl-2 derives its name from B-cell lymphoma 2 which came from being the second member of a range of proteins initially described as a reciprocal gene translocation in chromosomes 14 and 18 in follicular lymphomas. The genes and proteins can be either pro-apoptotic (Bax, BAD, Bak and Bok) or anti-apoptotic (Bcl-2, Bcl-xL, and Bcl-w).

Apoptosis is the programmed death of cells. It is central to the development and homeostasis of multicellular organisms, and it is the route by which unwanted or harmful cells are eliminated from the organism. The mitochondria is a large contributor in the subcellular partitioning of the apoptotic activator molecules such as cytochrome c. There are several triggering agents such as Ca2+, reactive oxygen species, certain lipid molecules and certain protein kinases that can induce MMP. The interaction opens the protein permeable pores that allow the release of several proteins including cytochrome c, Smac/Diablo, AIF, Endonuclease G, etc. Depending on their activated function, Bcl-2 either promotes the release or sequesters the function of the specific proteins.

Role in disease

Targeted Therapies