Michael Purol Sandbox 1
From Proteopedia
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{{STRUCTURE_1bd8 | PDB= 1bd8 | SCENE= }} | {{STRUCTURE_1bd8 | PDB= 1bd8 | SCENE= }} | ||
| - | == | + | ==p19 in the Cell Cycle== |
| - | CDK Inhibitor p19INK4d is a | + | CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase. |
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<scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene> | <scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene> | ||
Revision as of 12:43, 3 November 2009
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CDK Inhibitor p19INK4d
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| 1bd8, resolution 1.80Å () | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
p19 in the Cell Cycle
CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase.
