Michael Purol Sandbox 1
From Proteopedia
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{{STRUCTURE_1bd8 | PDB= 1bd8 | SCENE= }} | {{STRUCTURE_1bd8 | PDB= 1bd8 | SCENE= }} | ||
| - | == | + | ==p19INK4d in the Cell Cycle== |
CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors, which includes p16INK4a, p15INK4b,and p18INK4c. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase. The INK4 family members specifically bind to CDK4 and CDK6, inhibiting cyclin-CDK complexation and obstructing the progression of G1 phase. | CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors, which includes p16INK4a, p15INK4b,and p18INK4c. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase. The INK4 family members specifically bind to CDK4 and CDK6, inhibiting cyclin-CDK complexation and obstructing the progression of G1 phase. | ||
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To view p19INK4d bound to CDK6, click here: <scene name='Michael_Purol_Sandbox_1/Cdk6-p19ink4d_inhibitor_compl/1'>CDK6-p19INK4d inhibitor complex</scene> | To view p19INK4d bound to CDK6, click here: <scene name='Michael_Purol_Sandbox_1/Cdk6-p19ink4d_inhibitor_compl/1'>CDK6-p19INK4d inhibitor complex</scene> | ||
| - | + | ==p19INK4d Structure== | |
| + | The four INK4 proteins share a similar sturcture consisting of either four (p15 & p16) or five (p18 and '''p19''') ankyrin repeats (AR). | ||
<scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene> | <scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene> | ||
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<scene name='Michael_Purol_Sandbox_1/Ser_76/1'>Ser 76</scene> | <scene name='Michael_Purol_Sandbox_1/Ser_76/1'>Ser 76</scene> | ||
| - | + | ==Cancer== | |
Revision as of 13:42, 3 November 2009
Contents |
CDK Inhibitor p19INK4d
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| 1bd8, resolution 1.80Å () | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
p19INK4d in the Cell Cycle
CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors, which includes p16INK4a, p15INK4b,and p18INK4c. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase. The INK4 family members specifically bind to CDK4 and CDK6, inhibiting cyclin-CDK complexation and obstructing the progression of G1 phase.
To view p19INK4d bound to CDK6, click here:
p19INK4d Structure
The four INK4 proteins share a similar sturcture consisting of either four (p15 & p16) or five (p18 and p19) ankyrin repeats (AR).
Cancer
References
[1] Barrick D. (2009). Biological Regulation via Ankyrin Repeat Folding. Acs Chemical Biology 4,19-22.
[2] Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ and others. (1998). Crystal structure of the complex of the cyclin D dependent kinase Cdk6 bound to the cell-cycle inhibitor p19(INK4d). Nature 395,244-250.
[3] Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET. (2005). Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24,4065-4080.
[4] Low C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009). Conformational Switch upon Phosphorylation: Human CDK Inhibitor p19(INK4d) between the Native and Partially Folded State. Acs Chemical Biology 4,53-63.
[5] Thullberg M, Bartek J, Lukas J. (2000). Ubiquitin/proteasome-mediated degradation of p19(INK4d) determines its periodic expression during the cell cycle. Oncogene 19,2870-2876.
