1da2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1da2, resolution 1.700&Aring;" /> '''MOLECULAR AND CRYST...)
Line 1: Line 1:
-
[[Image:1da2.gif|left|200px]]<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1da2.gif|left|200px]]<br /><applet load="1da2" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1da2, resolution 1.700&Aring;" />
caption="1da2, resolution 1.700&Aring;" />
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''<br />
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''<br />
==Overview==
==Overview==
-
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its, hydrogen-bonding potential, since it forms stable base-pairs with both, adenine and guanine in oligomer duplexes. To investigate the base-pair, geometry, the structure of d(CGCGmo4CG) has been determined by, single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2, crystallized in a left-handed double helical structure (Z-type)., Refinement using 2559 reflections between 10 and 1.7 A converged with a, final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The, orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell, dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is, of the wobble type, with mo4C in the imino form, and the methoxy group in, the syn configuration.
+
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.
==About this Structure==
==About this Structure==
-
1DA2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].
+
1DA2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].
==Reference==
==Reference==
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2258939 2258939]
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2258939 2258939]
[[Category: Protein complex]]
[[Category: Protein complex]]
-
[[Category: Brown, D.M.]]
+
[[Category: Brown, D M.]]
[[Category: Kennard, O.]]
[[Category: Kennard, O.]]
-
[[Category: Lin, P.K.T.]]
+
[[Category: Lin, P K.T.]]
-
[[Category: Meervelt, L.Van.]]
+
[[Category: Meervelt, L Van.]]
-
[[Category: Moore, M.H.]]
+
[[Category: Moore, M H.]]
[[Category: double helix]]
[[Category: double helix]]
[[Category: modified]]
[[Category: modified]]
[[Category: z-dna]]
[[Category: z-dna]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:51:43 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:14:31 2008''

Revision as of 10:14, 21 February 2008

Image:1da2.gif

1da2, resolution 1.700Å

Drag the structure with the mouse to rotate

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA

Overview

The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.

About this Structure

1DA2 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:2258939

Page seeded by OCA on Thu Feb 21 12:14:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1da2"
Personal tools