2bg1
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2BG1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4 and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | + | 2BG1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4 and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BG1 OCA]]. |
==Reference== | ==Reference== | ||
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins., Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15637155 15637155] | Active site restructuring regulates ligand recognition in class A penicillin-binding proteins., Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15637155 15637155] | ||
| + | [[Category: Peptidoglycan glycosyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
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[[Category: peptidoglycan synthesis multifunctional enzyme]] | [[Category: peptidoglycan synthesis multifunctional enzyme]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:44:46 2007'' |
Revision as of 08:40, 30 October 2007
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ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASSA PENICILLIN-BINDING PROTEINS (PBPS)
Overview
Bacterial cell division is a complex, multimolecular process that requires, biosynthesis of new peptidoglycan by penicillin-binding proteins (PBPs), during cell wall elongation and septum formation steps. Streptococcus, pneumoniae has three bifunctional (class A) PBPs that catalyze both, polymerization of glycan chains (glycosyltransfer) and cross-linking of, pentapeptidic bridges (transpeptidation) during the peptidoglycan, biosynthetic process. In addition to playing important roles in cell, division, PBPs are also the targets for beta-lactam antibiotics and thus, play key roles in drug-resistance mechanisms. The crystal structure of a, soluble form of pneumococcal PBP1b (PBP1b*) has been solved to 1.9 A, thus, providing previously undescribed structural information regarding a class, A ... [(full description)]
About this Structure
2BG1 is a [Single protein] structure of sequence from [Streptococcus pneumoniae] with SO4 and CL as [ligands]. Active as [Peptidoglycan glycosyltransferase], with EC number [2.4.1.129]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins., Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. PMID:15637155
Page seeded by OCA on Tue Oct 30 10:44:46 2007
