1y4i
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1y4i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y4i, resolution 1.90Å" /> '''Crystal structure of...) |
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| - | [[Image:1y4i.gif|left|200px]]<br /><applet load="1y4i" size=" | + | [[Image:1y4i.gif|left|200px]]<br /><applet load="1y4i" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1y4i, resolution 1.90Å" /> | caption="1y4i, resolution 1.90Å" /> | ||
'''Crystal structure of Citrobacter Freundii L-methionine-lyase'''<br /> | '''Crystal structure of Citrobacter Freundii L-methionine-lyase'''<br /> | ||
==Overview== | ==Overview== | ||
| - | L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent | + | L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes gamma-elimination of L-methionine. The crystal structure of MGL from Citrobacter freundii has been determined at 1.9 A resolution. The spatial fold of the protein is similar to those of MGLs from Pseudomonas putida and Trichomonas vaginalis. The comparison of these structures revealed that there are differences in PLP-binding residues and positioning of the surrounding flexible loops. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y4I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Methionine_gamma-lyase Methionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.11 4.4.1.11] Full crystallographic information is available from [http:// | + | 1Y4I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Methionine_gamma-lyase Methionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.11 4.4.1.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4I OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of Citrobacter freundii L-methionine gamma-lyase., Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV, Acta | + | Structure of Citrobacter freundii L-methionine gamma-lyase., Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16511092 16511092] |
[[Category: Citrobacter freundii]] | [[Category: Citrobacter freundii]] | ||
[[Category: Methionine gamma-lyase]] | [[Category: Methionine gamma-lyase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Demidkina, T | + | [[Category: Demidkina, T V.]] |
| - | [[Category: Garber, M | + | [[Category: Garber, M B.]] |
| - | [[Category: Mamaeva, D | + | [[Category: Mamaeva, D V.]] |
| - | [[Category: Morozova, E | + | [[Category: Morozova, E A.]] |
| - | [[Category: Nikonov, S | + | [[Category: Nikonov, S V.]] |
| - | [[Category: Nikulin, A | + | [[Category: Nikulin, A D.]] |
| - | [[Category: Revtovich, S | + | [[Category: Revtovich, S V.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: plp-dependent enzyme]] | [[Category: plp-dependent enzyme]] | ||
[[Category: pyridoxal-5'-phosphate]] | [[Category: pyridoxal-5'-phosphate]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:01:42 2008'' |
Revision as of 14:01, 21 February 2008
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Crystal structure of Citrobacter Freundii L-methionine-lyase
Overview
L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes gamma-elimination of L-methionine. The crystal structure of MGL from Citrobacter freundii has been determined at 1.9 A resolution. The spatial fold of the protein is similar to those of MGLs from Pseudomonas putida and Trichomonas vaginalis. The comparison of these structures revealed that there are differences in PLP-binding residues and positioning of the surrounding flexible loops.
About this Structure
1Y4I is a Single protein structure of sequence from Citrobacter freundii with as ligand. Active as Methionine gamma-lyase, with EC number 4.4.1.11 Full crystallographic information is available from OCA.
Reference
Structure of Citrobacter freundii L-methionine gamma-lyase., Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:16511092
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