3kwf

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(New page: '''Unreleased structure''' The entry 3kwf is ON HOLD Authors: Hennig, M., Stihle, M., Thoma, R. Description: human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1...)
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'''Unreleased structure'''
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{{Seed}}
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[[Image:3kwf.jpg|left|200px]]
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The entry 3kwf is ON HOLD
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{{STRUCTURE_3kwf| PDB=3kwf | SCENE= }}
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Authors: Hennig, M., Stihle, M., Thoma, R.
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===human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one===
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Description: human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:45:27 2009''
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{{ABSTRACT_PUBMED_20031405}}
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==About this Structure==
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3KWF is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWF OCA].
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==Reference==
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<ref group="xtra">PMID:20031405</ref><references group="xtra"/>
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[[Category: Dipeptidyl-peptidase IV]]
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[[Category: Homo sapiens]]
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[[Category: Hennig, M.]]
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[[Category: Stihle, M.]]
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[[Category: Thoma, R.]]
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[[Category: Aminopeptidase]]
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[[Category: Cell membrane]]
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[[Category: Diabetes type ii]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:01:09 2010''

Revision as of 12:01, 13 January 2010

Template:STRUCTURE 3kwf

human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one

Template:ABSTRACT PUBMED 20031405

About this Structure

3KWF is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mattei P, Boehringer M, Di Giorgio P, Fischer H, Hennig M, Huwyler J, Kocer B, Kuhn B, Loeffler BM, Macdonald A, Narquizian R, Rauber E, Sebokova E, Sprecher U. Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1109-13. Epub 2009 Dec 6. PMID:20031405 doi:10.1016/j.bmcl.2009.12.024

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