2cca
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2CCA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 2CCA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Catalase Catalase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CCA OCA]]. |
==Reference== | ==Reference== | ||
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant., Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS, Biochemistry. 2006 Apr 4;45(13):4131-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16566587 16566587] | Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant., Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS, Biochemistry. 2006 Apr 4;45(13):4131-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16566587 16566587] | ||
| + | [[Category: Catalase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:49:47 2007'' |
Revision as of 08:45, 30 October 2007
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) AND S315T MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Overview
Inhibition of the enzyme Mycobacterium tuberculosis InhA (enoyl-acyl, carrier protein reductase) due to formation of an isonicotinoyl-NAD adduct, (IN-NAD) from isoniazid (INH) and nicotinamide adenine dinucleotide, cofactor is considered central to the mode of action of INH, a first-line, treatment for tuberculosis infection. INH action against mycobacteria, requires catalase-peroxidase (KatG) function, and IN-NAD adduct formation, is catalyzed in vitro by M. tuberculosis KatG under a variety of, conditions, yet a physiologically relevant approach to the process has not, emerged that allows scrutiny of the mechanism and the origins of INH, resistance in the most prevalent drug-resistant strain bearing, KatG[S315T]. In this report, we describe how hydrogen peroxide, delivered, at very low ... [(full description)]
About this Structure
2CCA is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with HEM as [ligand]. Active as [Catalase], with EC number [1.11.1.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant., Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS, Biochemistry. 2006 Apr 4;45(13):4131-40. PMID:16566587
Page seeded by OCA on Tue Oct 30 10:49:47 2007
