1mhk
From Proteopedia
(New page: 200px<br /><applet load="1mhk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mhk, resolution 2.50Å" /> '''Crystal Structure An...) |
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| - | [[Image:1mhk.gif|left|200px]]<br /><applet load="1mhk" size=" | + | [[Image:1mhk.gif|left|200px]]<br /><applet load="1mhk" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mhk, resolution 2.50Å" /> | caption="1mhk, resolution 2.50Å" /> | ||
'''Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn'''<br /> | '''Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A crystal structure has been obtained for a 26-nucleotide RNA that | + | A crystal structure has been obtained for a 26-nucleotide RNA that contains the loop E sequence from Chromatium minutissimum. Rather than having a loop E-like conformation, it consists of an A-form helix that splits into two separate strands following a sheared A-G base pair. The backbone of the strand containing the G of the A-G pair makes a turn of almost 180 degrees in the space of two nucleotides, and then interacts with the minor groove of the helix from which it originates. Similar structures, which we call hook-turns, occur in 16S and 23S rRNAs. They are found at places where the two strands of a helix separate at an A/G juxtaposition to interact with other sequences. |
==About this Structure== | ==About this Structure== | ||
| - | 1MHK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with BR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MHK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=BR:'>BR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHK OCA]. |
==Reference== | ==Reference== | ||
The crystal structure of a 26-nucleotide RNA containing a hook-turn., Szep S, Wang J, Moore PB, RNA. 2003 Jan;9(1):44-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12554875 12554875] | The crystal structure of a 26-nucleotide RNA containing a hook-turn., Szep S, Wang J, Moore PB, RNA. 2003 Jan;9(1):44-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12554875 12554875] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Moore, P | + | [[Category: Moore, P B.]] |
[[Category: Szep, S.]] | [[Category: Szep, S.]] | ||
[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
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[[Category: helix]] | [[Category: helix]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:12 2008'' |
Revision as of 11:55, 21 February 2008
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Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn
Overview
A crystal structure has been obtained for a 26-nucleotide RNA that contains the loop E sequence from Chromatium minutissimum. Rather than having a loop E-like conformation, it consists of an A-form helix that splits into two separate strands following a sheared A-G base pair. The backbone of the strand containing the G of the A-G pair makes a turn of almost 180 degrees in the space of two nucleotides, and then interacts with the minor groove of the helix from which it originates. Similar structures, which we call hook-turns, occur in 16S and 23S rRNAs. They are found at places where the two strands of a helix separate at an A/G juxtaposition to interact with other sequences.
About this Structure
1MHK is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of a 26-nucleotide RNA containing a hook-turn., Szep S, Wang J, Moore PB, RNA. 2003 Jan;9(1):44-51. PMID:12554875
Page seeded by OCA on Thu Feb 21 13:55:12 2008
Categories: Protein complex | Moore, P B. | Szep, S. | Wang, J. | BR | 180 degree turn | Helix
