3fhe

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3fhe.jpg|left|200px]]
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The entry 3fhe is ON HOLD until Mar 16 2011
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{{STRUCTURE_3fhe| PDB=3fhe | SCENE= }}
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Authors: Mamat, B., Davies, D.R.
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===Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine.===
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Description:
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:14:36 2009''
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{{ABSTRACT_PUBMED_19950900}}
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==About this Structure==
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3FHE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHE OCA].
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==Reference==
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<ref group="xtra">PMID:19950900</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Davies, D R.]]
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[[Category: Mamat, B.]]
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[[Category: Alternative splicing]]
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[[Category: Cytoplasm]]
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[[Category: Hydrolase]]
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[[Category: Leukotriene a4]]
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[[Category: Leukotriene b4 biosynthesis]]
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[[Category: Leukotriene biosynthesis]]
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[[Category: Lta4h]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Multifunctional enzyme]]
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[[Category: Peptidase]]
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[[Category: Protease]]
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[[Category: Structure based drug design]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:32:05 2010''

Revision as of 07:32, 6 January 2010

Template:STRUCTURE 3fhe

Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine.

Template:ABSTRACT PUBMED 19950900

About this Structure

3FHE is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sandanayaka V, Mamat B, Mishra RK, Winger J, Krohn M, Zhou LM, Keyvan M, Enache L, Sullins D, Onua E, Zhang J, Halldorsdottir G, Sigthorsdottir H, Thorlaksdottir A, Sigthorsson G, Thorsteinnsdottir M, Davies DR, Stewart LJ, Zembower DE, Andresson T, Kiselyov AS, Singh J, Gurney ME. Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis. J Med Chem. 2009 Dec 1. PMID:19950900 doi:10.1021/jm900838g

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