3kb5
From Proteopedia
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{{STRUCTURE_3kb5| PDB=3kb5 | SCENE= }} | {{STRUCTURE_3kb5| PDB=3kb5 | SCENE= }} | ||
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===PRY-SPRY domain of human TRIM72=== | ===PRY-SPRY domain of human TRIM72=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TRI72_HUMAN TRI72_HUMAN]] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB5 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019967786</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Jeong, B C.]] | [[Category: Jeong, B C.]] | ||
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[[Category: Gustavus]] | [[Category: Gustavus]] | ||
[[Category: High resolution]] | [[Category: High resolution]] | ||
| + | [[Category: Membrane protein]] | ||
[[Category: Mg53]] | [[Category: Mg53]] | ||
[[Category: Pry]] | [[Category: Pry]] | ||
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[[Category: Trim72]] | [[Category: Trim72]] | ||
[[Category: Tripartite motif]] | [[Category: Tripartite motif]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:56:34 2009'' | ||
Revision as of 02:20, 4 April 2013
Contents |
PRY-SPRY domain of human TRIM72
Function
[TRI72_HUMAN] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
About this Structure
3kb5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Park EY, Kwon OB, Jeong BC, Yi JS, Lee CS, Ko YG, Song HK. Crystal structure of PRY-SPRY domain of human TRIM72. Proteins. 2010 Feb 15;78(3):790-5. PMID:19967786 doi:10.1002/prot.22647
Categories: Homo sapiens | Jeong, B C. | Kwon, O B. | Park, E Y. | Song, H K. | B30 2 | Gustavus | High resolution | Membrane protein | Mg53 | Pry | Spry | Trim21 | Trim72 | Tripartite motif
