1uun
From Proteopedia
(New page: 200px<br /><applet load="1uun" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uun, resolution 2.5Å" /> '''MAIN PORIN FROM MYCOB...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size=" | + | [[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1uun, resolution 2.5Å" /> | caption="1uun, resolution 2.5Å" /> | ||
'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''<br /> | '''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Mycobacteria have low-permeability outer membranes that render them | + | Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models. |
==About this Structure== | ==About this Structure== | ||
| - | 1UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http:// | + | 1UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Faller, M.]] | [[Category: Faller, M.]] | ||
[[Category: Niederweis, M.]] | [[Category: Niederweis, M.]] | ||
| - | [[Category: Schulz, G | + | [[Category: Schulz, G E.]] |
[[Category: mycobacteria]] | [[Category: mycobacteria]] | ||
[[Category: porin]] | [[Category: porin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:34 2008'' |
Revision as of 13:28, 21 February 2008
|
MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)
Overview
Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.
About this Structure
1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.
Reference
The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314
Page seeded by OCA on Thu Feb 21 15:28:34 2008
