1v3o
From Proteopedia
(New page: 200px<br /><applet load="1v3o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v3o, resolution 1.7Å" /> '''Crystal structure of ...) |
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| - | [[Image:1v3o.gif|left|200px]]<br /><applet load="1v3o" size=" | + | [[Image:1v3o.gif|left|200px]]<br /><applet load="1v3o" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1v3o, resolution 1.7Å" /> | caption="1v3o, resolution 1.7Å" /> | ||
'''Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex'''<br /> | '''Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Recent genomic analyses revealed many kinds of tandem repeats of specific | + | Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats. |
==About this Structure== | ==About this Structure== | ||
| - | 1V3O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with K as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1V3O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: x-ray analysis]] | [[Category: x-ray analysis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:31:13 2008'' |
Revision as of 13:31, 21 February 2008
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Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex
Overview
Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats.
About this Structure
1V3O is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats., Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A, Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:15133122
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