3ky9

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3ky9.jpg|left|200px]]
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The entry 3ky9 is ON HOLD
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{{STRUCTURE_3ky9| PDB=3ky9 | SCENE= }}
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Authors: Tomchick, D.R., Rosen, M.K., Machius, M., Yu, B.
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===Autoinhibited Vav1===
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Description: Autoinhibited Vav1
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:33:06 2010''
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{{ABSTRACT_PUBMED_20141838}}
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==About this Structure==
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3KY9 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KY9 OCA].
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==Reference==
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<ref group="xtra">PMID:20141838</ref><ref group="xtra">PMID:18488041</ref><ref group="xtra">PMID:16285729</ref><ref group="xtra">PMID:11007481</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Machius, M.]]
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[[Category: Rosen, M K.]]
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[[Category: Tomchick, D R.]]
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[[Category: Yu, B.]]
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[[Category: Acetylation]]
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[[Category: Apoptosis]]
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[[Category: C1 domain]]
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[[Category: Calponin homology domain]]
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[[Category: Dbl homology domain]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Sh2 domain]]
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[[Category: Sh3 domain]]
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[[Category: Vav1]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:34:16 2010''

Revision as of 11:34, 25 February 2010

Image:3ky9.jpg

Template:STRUCTURE 3ky9

Autoinhibited Vav1

Template:ABSTRACT PUBMED 20141838

About this Structure

3KY9 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22;140(2):246-56. PMID:20141838 doi:10.1016/j.cell.2009.12.033
  • Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008 Jun;15(6):613-8. Epub 2008 May 18. PMID:18488041 doi:10.1038/nsmb.1428
  • Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 2005 Nov 22;44(46):15257-68. PMID:16285729 doi:10.1021/bi051126h
  • Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Sep 1;102(5):625-33. PMID:11007481

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