1z1y
From Proteopedia
(New page: 200px<br /><applet load="1z1y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z1y, resolution 2.000Å" /> '''Crystal structure o...) |
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| - | [[Image:1z1y.gif|left|200px]]<br /><applet load="1z1y" size=" | + | [[Image:1z1y.gif|left|200px]]<br /><applet load="1z1y" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1z1y, resolution 2.000Å" /> | caption="1z1y, resolution 2.000Å" /> | ||
'''Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax'''<br /> | '''Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax'''<br /> | ||
==Overview== | ==Overview== | ||
| - | P25 and P28 proteins are essential for Plasmodium parasites to infect | + | P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax] with YB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1Z1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1Y OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Plasmodium vivax]] | [[Category: Plasmodium vivax]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Garboczi, D | + | [[Category: Garboczi, D N.]] |
| - | [[Category: Klein, M | + | [[Category: Klein, M M.]] |
| - | [[Category: Long, C | + | [[Category: Long, C A.]] |
| - | [[Category: Saul, A | + | [[Category: Saul, A J.]] |
| - | [[Category: Saxena, A | + | [[Category: Saxena, A K.]] |
[[Category: Singh, K.]] | [[Category: Singh, K.]] | ||
| - | [[Category: Stowers, A | + | [[Category: Stowers, A W.]] |
| - | [[Category: Su, H | + | [[Category: Su, H P.]] |
[[Category: YB]] | [[Category: YB]] | ||
[[Category: four egf-like domains]] | [[Category: four egf-like domains]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:21 2008'' |
Revision as of 14:11, 21 February 2008
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Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax
Overview
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
About this Structure
1Z1Y is a Single protein structure of sequence from Plasmodium vivax with as ligand. Full crystallographic information is available from OCA.
Reference
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807
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