1ppb

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{{STRUCTURE_1ppb| PDB=1ppb | SCENE= }}
{{STRUCTURE_1ppb| PDB=1ppb | SCENE= }}
===THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT===
===THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT===
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{{ABSTRACT_PUBMED_2583108}}
{{ABSTRACT_PUBMED_2583108}}
==About this Structure==
==About this Structure==
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1PPB is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2002 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Thrombin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2002_1 10.2210/rcsb_pdb/mom_2002_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PPB OCA].
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[[1ppb]] is a 2 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2002 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Thrombin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2002_1 10.2210/rcsb_pdb/mom_2002_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PPB OCA].
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==See Also==
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*[[Ann Taylor 115|Ann Taylor 115]]
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*[[Serine protease|Serine protease]]
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*[[Thrombin|Thrombin]]
==Reference==
==Reference==
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<ref group="xtra">PMID:2583108</ref><references group="xtra"/>
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<ref group="xtra">PMID:002583108</ref><ref group="xtra">PMID:009263122</ref><ref group="xtra">PMID:012855810</ref><ref group="xtra">PMID:015311269</ref><ref group="xtra">PMID:016673263</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Bode, W.]]
[[Category: Bode, W.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 21 10:09:36 2010''
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[[Category: Serine proteinase]]

Revision as of 15:53, 27 July 2012

Image:1ppb.png


PDB ID 1ppb

Drag the structure with the mouse to rotate
1ppb, resolution 1.92Å ()
Ligands:
Activity: Thrombin, with EC number 3.4.21.5
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT

Template:ABSTRACT PUBMED 2583108

About this Structure

1ppb is a 2 chain structure of Thrombin with sequence from Homo sapiens. The January 2002 RCSB PDB Molecule of the Month feature on Thrombin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_1. Full crystallographic information is available from OCA.

See Also

Reference

  • Bode W, Mayr I, Baumann U, Huber R, Stone SR, Hofsteenge J. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J. 1989 Nov;8(11):3467-75. PMID:2583108
  • Yoneda T, Komooka H, Umeyama H. A computer modeling study of the interaction between tissue factor pathway inhibitor and blood coagulation factor Xa. J Protein Chem. 1997 Aug;16(6):597-605. PMID:9263122
  • Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003 Jul 11;301(5630):218-21. PMID:12855810 doi:http://dx.doi.org/10.1126/science.1084183
  • Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 doi:10.1038/nsmb811
  • Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb Hemost. 2006 Apr;32 Suppl 1:16-31. PMID:16673263 doi:10.1055/s-2006-939551

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