2x0u
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{Seed}} | {{Seed}} | ||
| - | [[Image:2x0u. | + | [[Image:2x0u.png|left|200px]] |
<!-- | <!-- | ||
| Line 12: | Line 12: | ||
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-AMINO SUBSTITUTED BENZOTHIAZOLE SCAFFOLD=== | ===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-AMINO SUBSTITUTED BENZOTHIAZOLE SCAFFOLD=== | ||
| + | |||
| + | <!-- | ||
| + | The line below this paragraph, {{ABSTRACT_PUBMED_20142040}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 20142040 is the PubMed ID number. | ||
| + | --> | ||
| + | {{ABSTRACT_PUBMED_20142040}} | ||
==About this Structure== | ==About this Structure== | ||
| Line 17: | Line 23: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:17015838</ref><references group="xtra"/> | + | <ref group="xtra">PMID:20142040</ref><ref group="xtra">PMID:17015838</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Basse, N.]] | [[Category: Basse, N.]] | ||
| Line 27: | Line 33: | ||
[[Category: Cancer]] | [[Category: Cancer]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
| - | [[Category: Host-virus interaction]] | ||
[[Category: Li-fraumeni drug discovery]] | [[Category: Li-fraumeni drug discovery]] | ||
[[Category: Metal binding]] | [[Category: Metal binding]] | ||
| Line 37: | Line 42: | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 09:21:55 2010'' |
Revision as of 07:21, 25 February 2010
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-AMINO SUBSTITUTED BENZOTHIAZOLE SCAFFOLD
Template:ABSTRACT PUBMED 20142040
About this Structure
2X0U is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Page seeded by OCA on Thu Feb 25 09:21:55 2010
