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3hxq

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[[Image:3hxq.png|left|200px]]
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===Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding===
===Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding===
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{{ABSTRACT_PUBMED_18025536}}
==About this Structure==
==About this Structure==
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3HXQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXQ OCA].
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[[3hxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXQ OCA].
==Reference==
==Reference==
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[[Category: Von willebrand disease]]
[[Category: Von willebrand disease]]
[[Category: Vwf]]
[[Category: Vwf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:54:28 2010''
 

Revision as of 18:17, 14 March 2011

Image:3hxq.png

Template:STRUCTURE 3hxq

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding

Template:ABSTRACT PUBMED 18025536

About this Structure

3hxq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007 Dec 4;116(23):2678-86. Epub 2007 Nov 19. PMID:18025536 doi:10.1161/CIRCULATIONAHA.107.724864
  • Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul;7(7):1155-62. Epub 2009 Apr 24. PMID:19422452 doi:10.1111/j.1538-7836.2009.03459.x

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