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User:Amy Kerzmann/Sandbox 5
From Proteopedia
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| - | == Serine Proteases == | + | == '''Serine Proteases''' == |
| - | + | The most famous members of the serine protease family are trypsin, chymotrypsin and elastase. These digestive enzymes are also useful tools in biochemistry and molecular biology to ascertain protein sequences. | |
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Serine proteases perform their catalytic roles using three key residues: Ser, His, Asp. Because the proteases utilize these three residues for function, they are referred to as the '''catalytic triad'''. Highlight the <scene name='User:Amy_Kerzmann/Sandbox_5/Chymotrypsin-triad/2' target='0'>chymotrypsin catalytic triad</scene>. Mouse over the structure to determine the residue numbers for Ser, Asp and His. | Serine proteases perform their catalytic roles using three key residues: Ser, His, Asp. Because the proteases utilize these three residues for function, they are referred to as the '''catalytic triad'''. Highlight the <scene name='User:Amy_Kerzmann/Sandbox_5/Chymotrypsin-triad/2' target='0'>chymotrypsin catalytic triad</scene>. Mouse over the structure to determine the residue numbers for Ser, Asp and His. | ||
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Now compare chymotrypsin to <scene name='User:Amy_Kerzmann/Sandbox_5/Trypsin-wt-triad/1' target='1'>trypsin catalytic triad</scene>. The <scene name='User:Amy_Kerzmann/Sandbox_5/Elastase-triad/2' target='2'>elastase catalytic triad</scene>. | Now compare chymotrypsin to <scene name='User:Amy_Kerzmann/Sandbox_5/Trypsin-wt-triad/1' target='1'>trypsin catalytic triad</scene>. The <scene name='User:Amy_Kerzmann/Sandbox_5/Elastase-triad/2' target='2'>elastase catalytic triad</scene>. | ||
Revision as of 09:13, 10 February 2010
Serine Proteases
The most famous members of the serine protease family are trypsin, chymotrypsin and elastase. These digestive enzymes are also useful tools in biochemistry and molecular biology to ascertain protein sequences.
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Serine proteases perform their catalytic roles using three key residues: Ser, His, Asp. Because the proteases utilize these three residues for function, they are referred to as the catalytic triad. Highlight the . Mouse over the structure to determine the residue numbers for Ser, Asp and His.
Now compare chymotrypsin to . The .
The contains Gly190, Val216 and Thr226.
