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3kq0
From Proteopedia
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{{STRUCTURE_3kq0| PDB=3kq0 | SCENE= }} | {{STRUCTURE_3kq0| PDB=3kq0 | SCENE= }} | ||
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===Crystal structure of human alpha1-acid glycoprotein=== | ===Crystal structure of human alpha1-acid glycoprotein=== | ||
| + | {{ABSTRACT_PUBMED_18823996}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/A1AG1_HUMAN A1AG1_HUMAN]] Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.<ref>PMID:17008009</ref> <ref>PMID:17321687</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3kq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bx6 3bx6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQ0 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018823996</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mueller, U.]] | [[Category: Mueller, U.]] | ||
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[[Category: Lipocalin]] | [[Category: Lipocalin]] | ||
[[Category: Plasma protein]] | [[Category: Plasma protein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Pyrrolidone carboxylic acid]] | [[Category: Pyrrolidone carboxylic acid]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 16:09:51 2010'' | ||
Revision as of 02:46, 4 April 2013
Contents |
Crystal structure of human alpha1-acid glycoprotein
Template:ABSTRACT PUBMED 18823996
Function
[A1AG1_HUMAN] Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.[1] [2]
About this Structure
3kq0 is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3bx6. Full crystallographic information is available from OCA.
Reference
- Schonfeld DL, Ravelli RB, Mueller U, Skerra A. The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. J Mol Biol. 2008 Dec 12;384(2):393-405. Epub 2008 Sep 16. PMID:18823996 doi:10.1016/j.jmb.2008.09.020
- ↑ Fitos I, Visy J, Zsila F, Mady G, Simonyi M. Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein. Biochim Biophys Acta. 2006 Nov;1760(11):1704-12. Epub 2006 Aug 25. PMID:17008009 doi:10.1016/j.bbagen.2006.08.015
- ↑ Zsila F, Iwao Y. The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra. Biochim Biophys Acta. 2007 May;1770(5):797-809. Epub 2007 Jan 28. PMID:17321687 doi:10.1016/j.bbagen.2007.01.009
