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3ky9

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Revision as of 13:23, 10 March 2010

Image:3ky9.png

Template:STRUCTURE 3ky9

Autoinhibited Vav1

Template:ABSTRACT PUBMED 20141838

About this Structure

3KY9 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22;140(2):246-56. PMID:20141838 doi:10.1016/j.cell.2009.12.033
  • Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008 Jun;15(6):613-8. Epub 2008 May 18. PMID:18488041 doi:10.1038/nsmb.1428
  • Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 2005 Nov 22;44(46):15257-68. PMID:16285729 doi:10.1021/bi051126h
  • Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Sep 1;102(5):625-33. PMID:11007481

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