We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Birrer Sandbox 2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Alcohol Dehydrogenase==
==Alcohol Dehydrogenase==
-
Alcohol dehydrogenase (ADH) is an enzyme that catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones through a mechanism that involves the removal of hydrogen. In the oxidation mechanism, ADH is momentarily associated with nicontinamide adenine dinucleotide (NAD+), which functions as a cosubstrate. The mechanism of the reaction is below:
+
Alcohol dehydrogenase (ADH) is an enzyme that catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones through a mechanism that involves the removal of hydrogen. {{STRUCTURE_1htb | PDB=1htb | SCENE= }}
-
CH3CH2OH + NAD+ → CH3COH (acetaldehyde) + NADH + H+ (Note: The reaction is actually reversible although the arrow does not show it)
+
In the oxidation mechanism, ADH is momentarily associated with nicontinamide adenine dinucleotide (NAD+), which functions as a cosubstrate. The mechanism of the reaction is below:
 +
CH3CH2OH + NAD+ → CH3COH (acetaldehyde) + NADH + H+ (Note: The reaction is actually reversible although the arrow does not show it) (citation needed)
 +
The alcohol dehydrogenase reaction is a bisubstrate reaction, where ADH catalyzed the transfer of a hydride ion from ethanol to NAD+. In metabolic reactions within the human liver, glyceraldehyde is reduced to glycerol through a mechanism in which NADH is reduced to NAD+, and this whole process is catalyzed by alcohol dehydrogenase.
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.
and display another structure.
- 
-
{{STRUCTURE_1htb | PDB=1htb | SCENE= }}
 

Revision as of 17:15, 1 March 2010

Alcohol Dehydrogenase

Alcohol dehydrogenase (ADH) is an enzyme that catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones through a mechanism that involves the removal of hydrogen.

PDB ID 1htb

Drag the structure with the mouse to rotate
1htb, resolution 2.40Å ()
Ligands: , , ,
Gene: HUMAN BETA3 CDNA (Homo sapiens)
Activity: Alcohol dehydrogenase, with EC number 1.1.1.1
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml 


In the oxidation mechanism, ADH is momentarily associated with nicontinamide adenine dinucleotide (NAD+), which functions as a cosubstrate. The mechanism of the reaction is below:

CH3CH2OH + NAD+ → CH3COH (acetaldehyde) + NADH + H+ (Note: The reaction is actually reversible although the arrow does not show it) (citation needed) The alcohol dehydrogenase reaction is a bisubstrate reaction, where ADH catalyzed the transfer of a hydride ion from ethanol to NAD+. In metabolic reactions within the human liver, glyceraldehyde is reduced to glycerol through a mechanism in which NADH is reduced to NAD+, and this whole process is catalyzed by alcohol dehydrogenase.


Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.

Proteopedia Page Contributors and Editors (what is this?)

David Birrer

Retrieved from "http://52.214.119.220/wiki/index.php/Birrer_Sandbox_2"
Personal tools