3ksq

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[[Image:3ksq.png|left|200px]]
 
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{{STRUCTURE_3ksq| PDB=3ksq | SCENE= }}
{{STRUCTURE_3ksq| PDB=3ksq | SCENE= }}
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===Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors===
===Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors===
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{{ABSTRACT_PUBMED_20056542}}
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==Function==
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[[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
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{{ABSTRACT_PUBMED_20056542}}
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==About this Structure==
==About this Structure==
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3KSQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSQ OCA].
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[[3ksq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSQ OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20056542</ref><references group="xtra"/>
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<ref group="xtra">PMID:020056542</ref><references group="xtra"/><references/>
[[Category: Protein farnesyltransferase]]
[[Category: Protein farnesyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:07:13 2010''
 

Revision as of 20:07, 4 April 2013

Template:STRUCTURE 3ksq

Contents

Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors

Template:ABSTRACT PUBMED 20056542

Function

[FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

About this Structure

3ksq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Zhu HY, Cooper AB, Desai J, Njoroge G, Kirschmeier P, Bishop WR, Strickland C, Hruza A, Doll RJ, Girijavallabhan VM. Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1134-6. Epub 2009 Dec 6. PMID:20056542 doi:10.1016/j.bmcl.2009.12.013

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