3k5u

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3k5u.jpg|left|200px]]
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The entry 3k5u is ON HOLD until Oct 08 2011
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{{STRUCTURE_3k5u| PDB=3k5u | SCENE= }}
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Authors: Wu, J.S., Leou, J.S., Coumar, M.S., Hsieh, H.P., Wu, S.Y.
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===Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor===
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Description: Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 15:21:22 2010''
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{{ABSTRACT_PUBMED_20039358}}
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==About this Structure==
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3K5U is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5U OCA].
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==Reference==
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<ref group="xtra">PMID:20039358</ref><ref group="xtra">PMID:19140666</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Coumar, M S.]]
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[[Category: Hsieh, H P.]]
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[[Category: Leou, J S.]]
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[[Category: Wu, J S.]]
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[[Category: Wu, S Y.]]
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[[Category: Atp-binding site]]
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[[Category: Aurora kinase inhibitor]]
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[[Category: Cell cycle]]
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[[Category: Cytoskeleton]]
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[[Category: H-bonding]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Virtual screening]]
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[[Category: X-ray co-crystal analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:47:02 2010''

Revision as of 07:37, 13 October 2010

Image:3k5u.jpg

Template:STRUCTURE 3k5u

Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor

Template:ABSTRACT PUBMED 20039358

About this Structure

3K5U is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP. Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor. ChemMedChem. 2010 Feb 1;5(2):255-67. PMID:20039358 doi:10.1002/cmdc.200900339
  • Coumar MS, Leou JS, Shukla P, Wu JS, Dixit AK, Lin WH, Chang CY, Lien TW, Tan UK, Chen CH, Hsu JT, Chao YS, Wu SY, Hsieh HP. Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. J Med Chem. 2009 Feb 26;52(4):1050-62. PMID:19140666 doi:10.1021/jm801270e

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