3lq8
From Proteopedia
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| + | {{STRUCTURE_3lq8| PDB=3lq8 | SCENE= }} | ||
| - | + | ===Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)=== | |
| - | Description: Structure of the kinase domain of c-Met bound to XL880 (GSK1363089) | ||
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| + | {{ABSTRACT_PUBMED_19808973}} | ||
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| + | ==Disease== | ||
| + | Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] | ||
| + | |||
| + | ==About this Structure== | ||
| + | 3LQ8 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQ8 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:19808973</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Receptor protein-tyrosine kinase]] | ||
| + | [[Category: Lougheed, J C.]] | ||
| + | [[Category: Stout, T J.]] | ||
| + | [[Category: Atp-binding]] | ||
| + | [[Category: Gsk1363089]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Kinase domain]] | ||
| + | [[Category: Nucleotide-binding]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Proto-oncogene]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transmembrane]] | ||
| + | [[Category: Tyrosine-protein kinase]] | ||
| + | [[Category: Xl880]] | ||
| + | |||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:29:59 2010'' | ||
Revision as of 06:30, 20 May 2010
Contents |
Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)
Template:ABSTRACT PUBMED 19808973
Disease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this Structure
3LQ8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Qian F, Engst S, Yamaguchi K, Yu P, Won KA, Mock L, Lou T, Tan J, Li C, Tam D, Lougheed J, Yakes FM, Bentzien F, Xu W, Zaks T, Wooster R, Greshock J, Joly AH. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009 Oct 15;69(20):8009-16. Epub 2009 Oct 6. PMID:19808973 doi:10.1158/0008-5472.CAN-08-4889
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