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3k5c

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Revision as of 07:07, 7 April 2010

Image:3k5c.png

Template:STRUCTURE 3k5c

Human BACE-1 complex with NB-216

Template:ABSTRACT PUBMED 19963375

About this Structure

3K5C is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lerchner A, Machauer R, Betschart C, Veenstra S, Rueeger H, McCarthy C, Tintelnot-Blomley M, Jaton AL, Rabe S, Desrayaud S, Enz A, Staufenbiel M, Paganetti P, Rondeau JM, Neumann U. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett. 2010 Jan 15;20(2):603-7. Epub 2009 Nov 22. PMID:19963375 doi:10.1016/j.bmcl.2009.11.092

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