3iut
From Proteopedia
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===The Crystal Structure of Cruzain in Complex with a Tetrafluorophenoxymethyl Ketone Inhibitor=== | ===The Crystal Structure of Cruzain in Complex with a Tetrafluorophenoxymethyl Ketone Inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_20088534}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3iut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUT OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020088534</ref><references group="xtra"/><references/> |
[[Category: Cruzipain]] | [[Category: Cruzipain]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
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[[Category: Thiol protease]] | [[Category: Thiol protease]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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Revision as of 09:20, 27 March 2013
Contents |
The Crystal Structure of Cruzain in Complex with a Tetrafluorophenoxymethyl Ketone Inhibitor
Template:ABSTRACT PUBMED 20088534
Function
[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
About this Structure
3iut is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
- Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for chagas disease chemotherapy. J Med Chem. 2010 Feb 25;53(4):1763-73. PMID:20088534 doi:10.1021/jm901633v
