1an8
From Proteopedia
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| - | [[Image:1an8.jpg|left|200px]]<br /><applet load="1an8" size=" | + | [[Image:1an8.jpg|left|200px]]<br /><applet load="1an8" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1an8, resolution 2.4Å" /> | caption="1an8, resolution 2.4Å" /> | ||
'''CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C'''<br /> | '''CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AN8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Known structural/functional Sites: <scene name='pdbsite=ZNA:This Site Also Includes HIS 81 From A Symmetry-Related M ...'>ZNA</scene> and <scene name='pdbsite=ZNB:This Site Also Includes HIS 35 And GLU 54 From A Symmetr ...'>ZNB</scene>. Full crystallographic information is available from [http:// | + | 1AN8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Known structural/functional Sites: <scene name='pdbsite=ZNA:This+Site+Also+Includes+HIS+81+From+A+Symmetry-Related+M+...'>ZNA</scene> and <scene name='pdbsite=ZNB:This+Site+Also+Includes+HIS+35+And+GLU+54+From+A+Symmetr+...'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:31:03 2008'' |
Revision as of 07:31, 3 February 2008
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CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C
Overview
Bacterial superantigens are small proteins that have a very potent, stimulatory effect on T lymphocytes through their ability to bind to both, MHC class II molecules and T-cell receptors. We have determined the, three-dimensional structure of a Streptococcal superantigen, SPE-C, at 2.4, A resolution. The structure shows that SPE-C has the usual superantigen, fold, but that the surface that forms a generic, low-affinity MHC-binding, site in other superantigens is here used to create a SPE-C dimer. Instead, MHC class II binding occurs through a zinc binding site that is analogous, to a similar site in staphylococcal enterotoxin A. Consideration of the, SPE-C dimer suggests a novel mechanism for promotion of MHC aggregation, and T-cell activation.
About this Structure
1AN8 is a Single protein structure of sequence from Streptococcus pyogenes. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules., Roussel A, Anderson BF, Baker HM, Fraser JD, Baker EN, Nat Struct Biol. 1997 Aug;4(8):635-43. PMID:9253413
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