1bsx
From Proteopedia
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| - | [[Image:1bsx.gif|left|200px]]<br /><applet load="1bsx" size=" | + | [[Image:1bsx.gif|left|200px]]<br /><applet load="1bsx" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bsx, resolution 3.7Å" /> | caption="1bsx, resolution 3.7Å" /> | ||
'''STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS'''<br /> | '''STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BSX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with T3 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=A:Nr-Box Binding Site'>A</scene> and <scene name='pdbsite=B:Nr-Box Binding Site'>B</scene>. Full crystallographic information is available from [http:// | + | 1BSX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=T3:'>T3</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=A:Nr-Box+Binding+Site'>A</scene> and <scene name='pdbsite=B:Nr-Box+Binding+Site'>B</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BSX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: specificity interaction site]] | [[Category: specificity interaction site]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:33:51 2008'' |
Revision as of 07:33, 3 February 2008
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STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS
Contents |
Overview
Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity.
Disease
Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]
About this Structure
1BSX is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:9808622
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