Molecular playground/beta 2 microglobulin
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
caption='β-2 Microglobulin' scene='Basic_view'/> | caption='β-2 Microglobulin' scene='Basic_view'/> | ||
| - | <scene name='User:Nick_Borotto/Sandbox_1/Basic_view/3'>β-2 Microglobulin</scene> is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually | + | <scene name='User:Nick_Borotto/Sandbox_1/Basic_view/3'>β-2 Microglobulin</scene> is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement. |
| + | |||
| + | The proposed mechanism for <scene name='User:Nick_Borotto/Sandbox_1/Proposed_dimer_structure/1'>Dimer</scene> | ||
| + | formation is that the copper binds near the N-terminal of the protein, this binding causes structural shifts throughout the protein creating two new planes that interact favorably. | ||
Revision as of 03:52, 30 April 2010
|
is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement.
The proposed mechanism for
formation is that the copper binds near the N-terminal of the protein, this binding causes structural shifts throughout the protein creating two new planes that interact favorably.
