3m36

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3m36.jpg|left|200px]]
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The entry 3m36 is ON HOLD
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{{STRUCTURE_3m36| PDB=3m36 | SCENE= }}
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Authors: Alexander, R.S.
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===Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)===
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Description: Factor XA in complex with the inhibitor 1-(3-(aminomethyl)phenyl)-n-(3-fluoro-2'-(methylsulfonyl)-4-biphenylyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (DPC423)
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:38:09 2010''
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{{ABSTRACT_PUBMED_14640539}}
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==About this Structure==
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3M36 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M36 OCA].
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==Reference==
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<ref group="xtra">PMID:14640539</ref><references group="xtra"/>
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
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[[Category: Alexander, R S.]]
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[[Category: Blood coagulation]]
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[[Category: Blood coagulation factor]]
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[[Category: Calcium- binding]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Disulfide bond]]
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[[Category: Egf-like domain]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Plasma]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Protein inhibitor complex]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:06:09 2010''

Revision as of 07:06, 21 April 2010

Image:3m36.jpg

Template:STRUCTURE 3m36

Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)

Template:ABSTRACT PUBMED 14640539

About this Structure

3M36 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h

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