3kmn
From Proteopedia
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{{STRUCTURE_3kmn| PDB=3kmn | SCENE= }} | {{STRUCTURE_3kmn| PDB=3kmn | SCENE= }} | ||
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===Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant=== | ===Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant=== | ||
| + | {{ABSTRACT_PUBMED_020540076}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMN OCA]. | |
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020540076</ref><references group="xtra"/><references/> | ||
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Glutathione]] | [[Category: Glutathione]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 02:40, 4 April 2013
Contents |
Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant
Template:ABSTRACT PUBMED 020540076
Function
[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.[1]
About this Structure
3kmn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, Garcia-Fuentes L. Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040. PMID:20540076 doi:10.1002/jmr.1040
- ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x
