Apurinic-Apyrimidinic Endonuclease

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=INTRODUCTION=
=INTRODUCTION=
APE1 is an endonuclease <ref>Barnes,T</ref>.
APE1 is an endonuclease <ref>Barnes,T</ref>.
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[[Image:APE!.png|250 px|right]]
[[Image:APE!.png|250 px|right]]
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[[Image:nucleasedomain.png|250 px|right]]
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APE1 works in the base excision repair pathway
APE1 works in the base excision repair pathway
<applet load='1de8' size='300' color='white' frame='true' align='left' caption='APE interacting with DNA'/>
<applet load='1de8' size='300' color='white' frame='true' align='left' caption='APE interacting with DNA'/>
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[[Image:BERpath.png|250 px|right]]
[[Image:BERpath.png|250 px|right]]
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[[Image:nucleasedomain.png|250 px|right]]

Revision as of 04:47, 25 March 2010

Contents

APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1)

INTRODUCTION

APE1 is an endonuclease [1].



Image:APE!.png



















STRUCTURE AND FUNCTION

APE1 works in the base excision repair pathway

APE interacting with DNA

Drag the structure with the mouse to rotate










Image:BERpath.png















Image:APEmech.png
Image:APEactivesite.png

















POPULATION VARIENTS

APE1 HAS BEEN SHOWN TO CLEAVE C-MYC MRNA





















Image:Nucleasedomain.png











REFERENCES

  1. ↑ Barnes,T
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