Sandbox 173
From Proteopedia
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| - | Rhodopsin is a highly characterized G protein-coupled receptor found in the neurons of the retina and in rod photoreceptor cells. It is part of the Class A (Family 1) of G protein-coupled receptors, a superfamily of membrane receptors with seven transmembrane helices<ref>Article 6</ref>. G protein-coupled receptors mediate responses to visual, olfactory, hormonal, and | + | Rhodopsin, a dimeric protein, is a highly characterized G protein-coupled receptor found in the neurons of the retina and in rod photoreceptor cells. It is part of the Class A (Family 1) of G protein-coupled receptors, a superfamily of membrane receptors with seven transmembrane helices<ref>Article 6</ref>. G protein-coupled receptors mediate responses to visual, olfactory, hormonal, and neurotransmitter signals among others<ref>Article 1</ref>. |
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{{STRUCTURE_1u19| PDB=1u19 | SCENE= }} | {{STRUCTURE_1u19| PDB=1u19 | SCENE= }} | ||
| - | ==Introduction== | ||
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==Structure== | ==Structure== | ||
| + | ===Characteristic G Protein-Coupled Receptor Architecture=== | ||
| + | Rhodopsin consists of seven mostly α-helical transmembrane domains (H1-H7)linked sequentially by extracellular and cytoplasmic loops (E1-E3 and C1-C3 respectively), with the extracellular amino-terminal tail and the cytoplasmic carboxyl-terminal tail<ref>Article 12</ref>. Four of the helices are tilted and three of the helices are approximately perpendicular to the membrane plane<ref>Article 4</ref>. | ||
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| - | ===Characteristic G Protein-Coupled Receptor Architecture=== | ||
| - | About this structure<ref>Testing out reference section, 2010 etc. Yay it works!</ref>. | ||
==Function== | ==Function== | ||
Revision as of 23:42, 25 March 2010
Rhodopsin, a dimeric protein, is a highly characterized G protein-coupled receptor found in the neurons of the retina and in rod photoreceptor cells. It is part of the Class A (Family 1) of G protein-coupled receptors, a superfamily of membrane receptors with seven transmembrane helices[1]. G protein-coupled receptors mediate responses to visual, olfactory, hormonal, and neurotransmitter signals among others[2].
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| 1u19, resolution 2.20Å () | |||||||||
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| Ligands: | , , , , , , , , | ||||||||
| Non-Standard Residues: | |||||||||
| Related: | 1f88, 1hzx, 1l9h | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Structure
Characteristic G Protein-Coupled Receptor Architecture
Rhodopsin consists of seven mostly α-helical transmembrane domains (H1-H7)linked sequentially by extracellular and cytoplasmic loops (E1-E3 and C1-C3 respectively), with the extracellular amino-terminal tail and the cytoplasmic carboxyl-terminal tail[3]. Four of the helices are tilted and three of the helices are approximately perpendicular to the membrane plane[4].
Function
Light-Induced Visual Signal Transduction
Light absorption and G protein activation
Opsin
References
- Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol. 2004 Sep 10;342(2):571-83. PMID:15327956 doi:10.1016/j.jmb.2004.07.044
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |
