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Sandbox 154

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== Structure of F-actin ==
== Structure of F-actin ==
<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
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<applet load='2zwh' size='200' color='white' frame='true' align='right' caption='Filamentous Actin (F-actin)'/>
<applet load='2zwh' size='200' color='white' frame='true' align='right' caption='Filamentous Actin (F-actin)'/>
=== Monomeric Unit - G-actin ===
=== Monomeric Unit - G-actin ===
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<applet load='1j6z' size='200' color='white' frame='true' align='right' caption='Globular Actin (G-actin): PDB identifier [http://www.rcsb.org/pdb/explore/explore.do?structureId=1J6Z/ 1J6Z]. G-actin constitutes the free monomeric form of actin. '/>
<applet load='1j6z' size='200' color='white' frame='true' align='right' caption='Globular Actin (G-actin): PDB identifier [http://www.rcsb.org/pdb/explore/explore.do?structureId=1J6Z/ 1J6Z]. G-actin constitutes the free monomeric form of actin. '/>
=== Domains ===
=== Domains ===

Revision as of 23:48, 25 March 2010

PDB ID 2zwh

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2zwh, resolution 3.30Å ()
Ligands: ,
Non-Standard Residues:


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

F-Actin

Filamentous actin (F-actin) is also referred to as microfilament [1] and is a highly conserved proteinous component found near ubiquitously in eukaryotic cytoskeletons. F-actin and other actin proteins generally provide a structural role to the cell.

History

The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. [2].

Introduction

Assembly

Structure of F-actin

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Filamentous Actin (F-actin)

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Monomeric Unit - G-actin

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Globular Actin (G-actin): PDB identifier 1J6Z. G-actin constitutes the free monomeric form of actin.

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Domains

Function

Enzymatic Role

Active Site

Ligand

Structural Role

References

  1. ↑ Microfilament - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilaments. Date accessed: March 16th, 2010.
  2. ↑ Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: 19158791







Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.
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