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Sandbox 154

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== Structure ==
== Structure ==
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<applet load='1j6z' size='175' color='white' frame='true' align='right' caption='Globular Actin (G-actin): PDB identifier [http://www.rcsb.org/pdb/explore/explore.do?structureId=1J6Z/ 1J6Z].'/>
<applet load='2zwh' size='175' color='white' frame='true' align='left' caption='Filamentous Actin (F-actin)'/>
<applet load='2zwh' size='175' color='white' frame='true' align='left' caption='Filamentous Actin (F-actin)'/>
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<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
 
=== History of the structure ===
=== History of the structure ===
The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. <ref> Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/19158791/ 19158791]</ref>.
The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. <ref> Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/19158791/ 19158791]</ref>.
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=== Polymer F-actin ===
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=== Monomeric Unit - G-actin ===
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Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . <ref> Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/2395461/ 2395461]</ref>.
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=== Monomeric Unit - G-actin ===
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<applet load='1j6z' size='175' color='white' frame='true' align='right' caption='Globular Actin (G-actin): PDB identifier [http://www.rcsb.org/pdb/explore/explore.do?structureId=1J6Z/ 1J6Z].'/>
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=== Polymer F-actin ===
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<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
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Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . <ref> Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/2395461/ 2395461]</ref>.
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Revision as of 00:59, 26 March 2010

PDB ID 2zwh

Drag the structure with the mouse to rotate
2zwh, resolution 3.30Å ()
Ligands: ,
Non-Standard Residues:


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

F-Actin

Filamentous actin (F-actin) is also referred to as microfilament [1] and is a highly conserved proteinous component found near ubiquitously in eukaryotic cytoskeletons. F-actin and other actin proteins generally provide a structural role to the cell.

Introduction

Actin is an important structural protein observed in eukaryotic cells, where it plays a large role in the cytoskeleton structure. There exist two forms of actin, globular (G-actin) and filamentous (F-actin). The monomeric protein units of G-actin compose the thin filaments of F-actin. F-actin largely comprises the eukaryotic cytoskeleton.

Assembly

Structure

Globular Actin (G-actin): PDB identifier 1J6Z.

Drag the structure with the mouse to rotate

Filamentous Actin (F-actin)

Drag the structure with the mouse to rotate

History of the structure

The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. [2].

Monomeric Unit - G-actin

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Polymer F-actin

Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . [3]. aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa






Domains

Function

Enzymatic Role

Active Site

Ligand

Structural Role

References

  1. ↑ Microfilament - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilaments. Date accessed: March 16th, 2010.
  2. ↑ Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: 19158791
  3. ↑ Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: 2395461







Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.
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