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C-JUN

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== Introduction ==
== Introduction ==
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C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein <ref>PMID:8662824</ref>. C-Jun is a transcriptional activator <ref>PMID:8662824</ref>. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes <ref>PMID:8662824</ref>.
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C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein <ref name="ref1"/>. C-Jun is a transcriptional activator <ref name="ref1"/>. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes <ref name="ref1"/>.
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<applet load='1Z82' size='300' frame='true' align='right' caption='1JUN' />
<applet load='1Z82' size='300' frame='true' align='right' caption='1JUN' />
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This protein is a dimer that is completely symmetrical (a). It is comprised of coiled coil of two alpha helices (a).
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This protein is a dimer that is completely symmetrical <ref name="ref2"> A Junius, F.K., Mackay, J.P., Bubb, W.A., Jensen, S.A., Weiss, A.S., King, G.F. 2006. Nuclear Magnetic Resonance Characterization of the Jun Leucine Zipper Domain: Unusual Properties of Coiled-Coil Interfacial Polar Residues? </ref>(a). It is comprised of coiled coil of two alpha helices <ref name="ref2">.

Revision as of 19:32, 30 March 2010

Andrew Rebeyka

C-JUN

The C-Jun protein belongs the member of the basic region leucine zippere (bZIP) family of transcription factors. All these factors bind to DNA as either homo or heterodimers [1]. This union of the two identical molecular units is mediated by each of their leucine zipper domains and subsequently a prerequisite to the binding of their related DNA enhancer elements [1]. This prerequisitie is needed as dimerization enables the alpha helical DNA binding domains to be inserted into adjacent grooves of the dyad symmetrical DNA recognition site. this therefore affects the activity of how these proteins are regulated by causing these protein to protein interactions between the leucine zipper domains in addition to the interactions between protein and DNA [1].


Introduction

C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein [1]. C-Jun is a transcriptional activator [1]. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes [1].


Structural Overview

Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.

1JUN

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This protein is a dimer that is completely symmetrical [2](a). It is comprised of coiled coil of two alpha helices [2]
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