C-JUN
From Proteopedia
| Line 4: | Line 4: | ||
= C-JUN = | = C-JUN = | ||
| - | <applet load='1Z82' size=' | + | |
| + | <applet load='1Z82' size='200' frame='true' align='right' caption='1JUN' /> | ||
| + | |||
| + | == Introduction == | ||
The c-Jun protein is a member of transcription factors which consist of a basic region leucine zipper region <ref name="ref1"> PMID:8662824 </ref>. All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers <ref name="ref1"/>.. In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands. Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation <ref name="ref1"/>. Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein interactions between each of the leucine zipper domains <ref name="ref1"/>. | The c-Jun protein is a member of transcription factors which consist of a basic region leucine zipper region <ref name="ref1"> PMID:8662824 </ref>. All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers <ref name="ref1"/>.. In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands. Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation <ref name="ref1"/>. Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein interactions between each of the leucine zipper domains <ref name="ref1"/>. | ||
| - | == | + | == XXX == |
C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein <ref name="ref1"/>. C-Jun is a transcriptional activator <ref name="ref1"/>. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes <ref name="ref1"/>. | C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein <ref name="ref1"/>. C-Jun is a transcriptional activator <ref name="ref1"/>. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes <ref name="ref1"/>. | ||
Revision as of 03:11, 1 April 2010
Andrew Rebeyka
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |
Contents |
C-JUN
|
Introduction
The c-Jun protein is a member of transcription factors which consist of a basic region leucine zipper region [1]. All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers [1].. In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands. Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation [1]. Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein interactions between each of the leucine zipper domains [1].
XXX
C-Jun binds to specific DNA sites either in the homodimer or deterodimer forms with the aid of C-Fos protein [1]. C-Jun is a transcriptional activator [1]. C-jun, with the aid of C-Fos represents a crucial union between normal and uncontrolled cell growth as their combined role in the transduction of afferent growth signals the response of specific genes [1].
Structural Overview
This protein is a dimer that is completely symmetrical [2](a). It is comprised of coiled coil of two alpha helices [2]Proteopedia Page Contributors and Editors (what is this?)
Andrew Rebeyka, Michal Harel, Alexander Berchansky, David Canner, Andrea Gorrell
