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User:Christopher Koehn/sandbox 1
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== Structure == | == Structure == | ||
| - | <applet load='3KDP' size=' | + | <applet load='3KDP' size='300' frame='true' align='left' scene='User:Christopher_Koehn/sandbox_1/Monomer/5' target='0' caption='Na-K Pump; α-subunit in blue, β-subunit in green, and FXYD subunit in yellow' /> |
The Na<sup>+</sup>-K<sup>+</sup> pump is a P-type ATPase with a structure highly similar to the H<sup>+</sup>-K<sup>+</sup>-ATPase and somewhat similar to the sarco(endo)plasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA)[http://www.proteopedia.org/wiki/index.php/2by4]. Overall, the structure of the sodium-potassium-pump is a transmembrane protein with three subunits. The α-subunit is the largest subunit and contains the binding sites for Na<sup>+</sup>, K<sup>+</sup>, and ATP. | The Na<sup>+</sup>-K<sup>+</sup> pump is a P-type ATPase with a structure highly similar to the H<sup>+</sup>-K<sup>+</sup>-ATPase and somewhat similar to the sarco(endo)plasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA)[http://www.proteopedia.org/wiki/index.php/2by4]. Overall, the structure of the sodium-potassium-pump is a transmembrane protein with three subunits. The α-subunit is the largest subunit and contains the binding sites for Na<sup>+</sup>, K<sup>+</sup>, and ATP. | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 21:11, 6 April 2010
Introduction to Sodium-Potassium-ATPases
The sodium-potassium-ATPase, also known as the Na+-K+ pump is the protein responsible for the ATP-dependent coupled transport of sodium and potassium ions across the plasma membrane. The Na+-K+ pump is found in all animal cells and is a major force in maintaining the concentration gradients of these ions across the membrane. These gradients provide energy for several cellular functions including control of membrane potential, cell size, and pH homeostasis, and nutrient uptake. Each cycle of ATP hydrolysis, the protein transports three Na+ ions out of the cell and two K+ ions across the plasma membrane into the cell. In addition to its role as a transport protein, the sodium-potassium-pump has also been shown to act as a receptor for cardiotonic steroid signalling.
Structure
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The Na+-K+ pump is a P-type ATPase with a structure highly similar to the H+-K+-ATPase and somewhat similar to the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)[1]. Overall, the structure of the sodium-potassium-pump is a transmembrane protein with three subunits. The α-subunit is the largest subunit and contains the binding sites for Na+, K+, and ATP.
