1gxr
From Proteopedia
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| - | [[Image:1gxr.gif|left|200px]]<br /><applet load="1gxr" size=" | + | [[Image:1gxr.gif|left|200px]]<br /><applet load="1gxr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gxr, resolution 1.65Å" /> | caption="1gxr, resolution 1.65Å" /> | ||
'''WD40 REGION OF HUMAN GROUCHO/TLE1'''<br /> | '''WD40 REGION OF HUMAN GROUCHO/TLE1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GXR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CA:Ca Binding Site For Chain A'>CA</scene>. Full crystallographic information is available from [http:// | + | 1GXR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CA:Ca+Binding+Site+For+Chain+A'>CA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: wd40]] | [[Category: wd40]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:43:53 2008'' |
Revision as of 07:43, 3 February 2008
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WD40 REGION OF HUMAN GROUCHO/TLE1
Overview
Groucho (Gro)/TLE proteins are transcriptional corepressors that lack, inherent DNA binding but interact with DNA-bound transcription factors and, histones, and recruit histone deacetylases. Groucho-mediated repression is, essential in embryonic development and involved in regulation of Wnt, signaling in adult tissue. We have determined the 1.6 A crystal structure, of a C-terminal fragment of human Groucho/TLE1, comprising part of the, Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions. The structure confirms the, relationship to the yeast Tup1 corepressor, but reveals important, structural differences specific to the metazoan system. Analysis of, missense mutations in the C. elegans Groucho homolog UNC-37 identifies, sites of interaction with repression effectors, and suggests an induced, fit binding site for eh1 domains of Engrailed-type transcription factors.
About this Structure
1GXR is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor., Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH, Structure. 2002 Jun;10(6):751-61. PMID:12057191
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