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3mcf
From Proteopedia
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Revision as of 23:22, 10 April 2013
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Function
[NUD10_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
About this Structure
3mcf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Arrowsmith, C H. | Berg, S van der. | Berglund, H. | Bountra, C. | Collins, R. | Edwards, A M. | Flodin, S. | Flores, A. | Graslund, S. | Hammarstrom, M. | Johansson, I. | Karlberg, T. | Kol, S. | Kotenyova, T. | Moche, M. | Nordlund, P. | Nyman, T. | Persson, C. | SGC, Structural Genomics Consortium. | Schuler, H. | Schutz, P. | Siponen, M I. | Thorsell, A G. | Tresaugues, L. | Wahlberg, E. | Weigelt, J. | Welin, M. | Wisniewska, M. | Aps2 | Diphosphoinositol pentakisphosphate | Dipp3a | Hydrolase | Metal-binding | Nudix | Nudt10 | Sgc | Sgc stockholm | Signal transduction | Structural genomic | Structural genomics consortium
